(1) The subject developed, firstly, the typical gleet of gonorrhoea, then went on to produce a chancre and then the manifestations of secondary syphilis.(2) Secondary syphilis develops several weeks to months after the chancre appears.(3) The first symptom to appear is a painless chancre at the point of the microbe's entry - it is in contact with these chancres that transmission occurs.(4) Primary syphilis is most often associated with a single, painless chancre, although it can manifest in other ways (i.e., multiple chancres , painful papules or ulcers, or no lesions).(5) In addition to leprosy, foreigners seeking work permits are now required to be tested for tuberculosis and the sexually transmitted diseases syphilis, chlamydia and chancres .
