(1) Anemia with thrombocytopenia indicates leukemia, systemic lupus erythematosus or aplastic anemia.(2) Splenomegaly or giant hemangioma can result in thrombocytopenia because of platelet sequestration.(3) Purpura may be secondary to thrombocytopenia , platelet dysfunction, coagulation factor deficiency or vascular defect.(4) Hemolytic-uremic syndrome is characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute renal injury.(5) Chronic inhalation abuse may also cause bone marrow depression resulting in leukopenia, anemia, thrombocytopenia , leukemia, and hemolysis.
